徐浩东：加州大学洛杉矶分校大卫格芬医学院，病理学与实验医学部教授。
教育背景：
本科：苏州大学医学院，1982.09——1987.08
硕士：苏州大学医学院，方向：循环生理学，1987.09——1990.07
博士：苏州大学医学院，方向：心脏生理学，1990.09——1993.07
学术职位职务：
1990.07——09;1993.09——11
Research Fellow 苏州大学医学院第一附属医院心内科
1993.11——1999.06
博士后，美国华盛顿大学医学院，分子生物学和药理学
1999.07——2001.06
解剖病理学住院医师，美国华盛顿大学医学院，病理学与免疫学系
2001.07——2002.06
住院医师和博士后，美国华盛顿大学医学院，病理学与免疫学系
研究领域：KChIP2 和丝蛋白 C在小鼠心室肌细胞电压门控钾通道产生中的作用
2002.07——2003.06
解剖病理学住院医师，美国华盛顿大学医学院，病理学与免疫学系
2003.07——2004.06
Fellow,美国华盛顿武装部队病理学研究所，肺与纵隔病理学系
2004.07——2008.04
助理教授，美国罗彻斯特大学医学与口腔学院，病理学与实验医学部
2008.05——2011.11
副教授，美国罗彻斯特大学医学与口腔学院，病理学与实验医学部
2011.12——2013.07
教授，美国罗彻斯特大学医学与口腔学院，病理学与实验医学部
2013.08至今
教授，加州大学洛杉矶分校大卫格芬医学院，病理科和实验医学部
医疗执照与委员会证明：
华盛顿永久执照
纽约永久执照
加利福尼亚州行医执照
解剖病理学委员会认证
专业社团成员：
美国－加拿大病理学会
美国心脏病学会
中美病理家协会 副会长（3/2012-3/2013)
编委会成员：
人体病理学杂志
免疫组化和分子学应用杂志
生物医学和生物技术杂志
世界消化道肿瘤杂志
中国临床医学杂志
临床与实验病理学杂志
组织学与组织病理学
中国现代医学杂志
临床专长：
外科病理学，尤其是肺和纵隔病理学，心脏病理学，和免疫组织化学
研究兴趣：
基础科学：
定义了p90RSK激活延长心脏复极化及其在心律失常发展中发挥重要作用的分子机制
临床translational研究：
确定恶性肿瘤中癌蛋白的表达方式，特别是肺癌，鉴别用于诊断和预后的有用的生物学标记
专业服务：
罗彻斯特大学医学中心生物医学和健康科学毕业生程序成员
期刊杂志评审小组成员，范围包括人类病理学，应用免疫组织化学和分子形态学，外科病理学国际性期刊
奖励和荣誉：
“优秀学生奖学金”，苏州大学医学院(1982-1987)
班长，苏州大学医学院(1982-1987)
Zhou, Wenxun奖学金(1992)
硕士班长(1987-1990)
论文获第六届心脏起搏与电生理学研讨会“杰出青年论文奖”， 中国武汉，10.19-21, 1992.
论文获第四届心脏病学研讨会“优秀论文奖”，中国西安，10 .14-16, 1993
NIH“膜片钳技术应用”三等奖，中国，1996
NIH心血管训练奖助金(10. 1997-6.1999)
NIH心血管训练奖助金(7, 1, 2001-6, 30, 2002)
Culpeper基金，合作研究，“磁共振成像识别冠状动脉瓣膜破裂倾向”， PI: Jie Zheng博士 (1, 1, 2002-12, 31, 2002)
华夏病理学教学奖（2010年）
病理与实验医学部Eric A. Schenk优秀老师（2010）
现有奖助金：
NIH R01奖助金，PI“Wnt/β-catenin 信号和 心脏 Na+通路” (1/1/2015–1/1/ 2020).
AHA Grant-in-Aid，PI“ ROS介导抑制NaV1.5中Foxo1的作用”（1/1/2012-12/31/2014 ）
NIH R01奖助金,合作研究,"细胞特异性基因和药物传递的DNA核序列导入"(9/30/2010- 8/31/2014 )
NIH K08奖助金，PI，“激酶对Ito,f的调节在心律异常中的作用” (8/15/2007–4/ 30/ 2012).
NIH R01奖助金，合作研究(PI: Chen Yan) “磷酸二酯酶在心脏中的调节与功能” (12/1/2007 – 11/30/2012)
科学与健康研究所奖助金，合作研究(PI: Irfan Rahman),“慢性阻塞性肺疾病中吸烟相关肺部炎症的分子机制” (7/1/2008 – 6/30/2011).
教育贡献：
大二医学生生理学，苏州大学医学院，1988
大三医学生心电图学，苏州大学医学院，1990
罗彻斯特大学医学中心教学贡献如下：
病理学住院医师教学：
5-6小时/天，外科病理学签发
3-4小时/天，冰冻切片
每年6次，一小时讨论会，大体与冰冻切片诊断技术
每年2次，一小时讲座，解剖教学（肺与纵隔病理学）
医学生：
常年病理住院医师教学
偶尔参加病理实验室会议
博士生：
每年2次，一小时演讲，心血管生物学课程（心脏解剖与发育，心律失常）
每年2次，两小时演讲，病理学课程（心脏病理学，心脏电生理学）
指导医师临床translational研究:
细胞病理学医师、住院医师和医学生参与过我的临床translational研究。我对方案提出意见，并帮助设计方案，撰写草稿。他们当中大部分均在USCAP会议上发表过摘要，并以第一作者发表过论文和/或摘要。（见出版物）
指导博士后和大学生基础研究：
博士后Zhibo Lu随我一起工作两年多。他在我们部门研究期间两次提出数据。2007年他在佛罗里达州奥兰多市的AHA科学研讨会上发表了我们的摘要。
罗彻斯特大学四年级学生Sheng Ping Xu随我一同工作两个多月。他学习了分子生物学的一些基本技术，为实验室配置缓冲液。
同行评议稿:
1. Huang WQ, Zhao, WW, Xu H, Xu B and Yu ZM. Comparison of effects of 4 anesthetics on carotid sinus reflex in rats. Chinese Journal of Applied Physiology 7:227-232 (1991).
2. Huang, WQ, Xu H, Wu X, Xu B and Yu ZM. Role of the central a receptors in the modulation of carotid reflex of rats. Sheng Li Xue Bao 44:556-561 (1992).
3. Xu H, Huang WQ, Zhao WW, Xu, B and Yu ZM. Effect of the central noradrenergic system of carotid sinus reflex in rats. Sheng Li Xue Bao 44:127-132 (1992).
4. Xu H and Jiang WP. Recording potassium, calcium and sodium currents of ventricular cells using patch-clamp technique. Pace and Heart (Chinese) 7:9-11 (1993).
5. Jiang WP and Xu H. Studies of activity of ionic channels and its applications. Zhonghua Xin Xue Guan Bing Za Zhi 22:55-56 (1994).
6. Xu H, Qiu CG and Jiang WP. Studies on electrophysiology of lysophosphatidylcholine and evaluation of its clinical significance. Zhonghua Nei Ke Za Zhi 33:519-523 (1994).
7. Xu H, Dixon JE, Barry DM, Trimmer JS, McKinnon D, Merlie JP and Nerbonne JM. Developmental analysis reveals mismatch in the expression of K+ channel a subunits and voltage-gated K+ channel currents in rat ventricular myocytes. Journal of General Physiology 40:444-478 (1996).
8. Barry DM, Xu H, Schuessler RB and Nerbonne JM. Functional knockout of the cardiac transient outward K+ current in mice expressing a dominant negative voltage-gated K+ channel (Kv4) a subunit. Circulation Research 83:560-567 (1998).
9. Xu H, Li H and Nerbonne JM. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 a subunit. Journal of Physiology 519:11-21 (1999).
10. Xu H, Guo W and Nerbonne JM. Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. Journal of General Physiology 113: 661-677 (1999).
11. Guo W, Xu H, London B and Nerbonne JM. Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. Journal of Physiology 521:587-599 (1999).
12. Xu H, Barry MD, Li H, Brunet S, Guo W and Nerbonne JM. Attenuation of the slow component of delay rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 a subunit. Circulation Research 85:623-633 (1999).
13. Li H, Guo W, Xu H, and Nerbonne JM. Functional expression of a GFP-tagged Kv1.5 a subunit in mouse ventricle. American Journal of Physiology-Heart 281:H955-967 (2001).
14. Sundt TM, Moon MR and Xu H. Reoperation for dilatation of the pulmonary autograft after Ross procedure. Journal of Thoracic and Cardiovascular Surgery 122:1249-1252 (2001).
15. Goldstein JA, Beardslee MA, Xu H, Sundt TM and Lasala J. Infective endocarditis on a CardioSEAL Device closing a patent formen ovale. Catheterization and Cardiovascular Interventions. 55:217-220 (2002).
16. Okamato R, Xu H, Kouchoukos N, Moon MR and Sundt TM. The influence of medical properties on wall stress and distensibility of the dilated ascending aorta. Journal of Thoracic and Cardiovascular Surgery 126:842-850 (2003).
17. Xu H, Lu D, EL-Mofty SK and Wang H. Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: associated with human papillomavirus 11 and lack of aberrant p53, Rb and p16 protein expression. Human Pathology 5:1419-1422 (2004).
18. Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS and Schaffer JE. Transgenic expression of FATP1 in the heart causes lipotoxic cardiomyopathy.
Circulation Research 96:225-233 (2005).
19. Ding B, Abe JI, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC and Yan C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proceedings of the National Academy of Sciences 102:14771-14776 (2005).
20. Guo W, Tung WE, Marionneau C, Aimond F, Xu H, Yamada KA, Schwartz TL, Demolombe S and Nerbonne JM. Targeted deletion of Kv4.2 eliminates Ito,f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circulation Research 97: 1342-1350 (2005).
21. Bhagwat SP, Gigliotti F, Xu H and Wright TW. Contribution of T cell subsets to the pathophysiology of pneumocystis-related immunorestitution disease. American Journal Physiology-Lung Cell Mol Physiol 291:L1256-66 (2006).
22. Shah AP, Xu H, P.J. Sime PJ and Trawick DR. Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome. European Respiratory Journal 28:1276-1279 (2006).
23. Wagner D, Joseph J, Huang J and Xu H*. Malakoplakia of the prostate on needle core biopsy: a case report and review of the literature. The International Journal of Surgical Pathology 15: 86-89 (2007).
24. Hameed O, Xu H, Saddeghi S and Maluf H. Pancreatic neuroendocrine carcinoma with prominent hepatocellular differentiation. American Journal Surgical pathology 31:146-152 (2007).
26. Xu H*, Bourne PA, Spaulding BO and Wang HL. High grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer (KOC) but carcinoid tumors do not. Human Pathology 38:556-563 (2007).
27. Ishinaga H, Jono H, Jae Hyang Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Feng XH, Chen LF and Jian-Dong Li JD. TGF-b induces p65 acetylation to enhance Bacteria-induced NF-kB activation. EMBO Journal 26:1150-1162 (2007).
28. Yan C, Ding B, Shishido T, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, and Abe JI. Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. Circulation Research 100: 510-519 (2007).
29. Simon R, Bourne PA, Yang Q, Spaulding BO, di Sant'Agnese PA, Wang HL and Xu H*. Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer (KOC) but carcinoid tumors do not. Human Pathology 38:1178-1183 (2007).
30. Lim JH, Stirling B, Derry J, Koga, T, Jono H, Woo CH, Xu H, Bourne PA, Ha UH, Ishinaga H, Xu H, Andalibi, A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA and Li JD. Tumor suppressor CYLD acts as a crucial regulator of acute lung injury in lethal streptococcus pneumoniae infections. Immunity 27: 249-60 (2007).
31. Miyamoto H, Molena DA, Schoeniger LO, and Xu H*. Solitary fibrous tumor of the pancreas: a case report. International Journal of Surgical Pathology 15: 311- 314 (2007).
32. Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD.Tumor Suppressor CYLD Acts as a Negative Regulator for Non-Typeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice. PLoS ONE.10; e1032 (2007).
33. LaPoint RJA, Bourne PA, Wang HL and Xu H*. Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. Applied Immunohistochemistry & Molecular Morphology, 15:401-406 (2007).
34. Hanley KZ, Facik MS, Bourne, PA, Yang Q, Spaulding, BO, Bonfiglio, TA and Xu H*. Utility of Anti-L523S Antibody in the Diagnosis of Benign malignant serous effusions. Cancer Cytopathology 25;114:49-56 (2008).
35. Pryor JG, Bourne PA, Yang Q, Spaulding BO, Scott GA and Xu H*. IMP3 is a progression marker in malignant melanoma. Modern pathology 21:431-437(2008).
36. Wagner D, Bourne PA, Yang Q, Goldman BI, Lewis, JS, and Xu H*. Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. Applied Immunohistochemistry and Molecular Morphology, in press.
37. Lester, T and Xu H*. Malignant pleural mesothelioma with osseousmetastases and pathologic fracture of femoral neck: a case report. Applied Immunohistochemistry and Molecular Morphology. in press.
38. Li L, Xu H, Spaulding BO, Cheng L, Simon R, Yao JL, P. Anthony di Sant’Agnese AP, Patricia A. Bourne, PA and Huang J. Expression of KOC (K-domain protein overexpressed in human cancer) in benign urothelium and urothelial tumors. Human Pathology. in press.
39. Miyamoto H, Jones CE, Raymond DP, Strang J, Wandtke JC, Bourne PA and Xu H*. Pulmonary metastases from uterine neoplasms after long tumor-free interval: Four cases and review of the literature. Pathology. in press.
40. Lu Z, Abe JI, Taunton J, Schishido, T McClain C, Yan C, Xu SP and Xu H*. Reactive oxygen species-Induced p90 ribosomal S6 kinase activation leads to prolongation of cardiac repolarization via Inhibiting voltage-gated outward K+ currents. Circulation Research. in revision.
41. Fallone E, Bourne PA, Watson TJ, Ghossein R, Travis WD and Xu H*. Parathyroid adenoma with prominent lymphocytic infiltration in the mediastinum. Applied Immunohistochemistry and Molecular Morphology. in revision.
42. Simon RA, di Sant’Agnese PA, Xu H, Yao JL, Qi Y, Bourne PA, Liang S, Liu J, Wei J, Cheng L, Oh WK and Huang J. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Submitted to Clinical Cancer Research.
43. Pryor JG, Simon RA, Bourne PA, Spaulding BO, Scott GA and Xu H*. Merkel cell carcinomas express K homology domain containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas. Submitted to Human Pathology.
44. Ling C, Ji C, Raymond PA, Bourne PA and Xu H*. Unusual features of pulmonary Langerhans’ cell histiocytosis. Submitted to Human Pathology.
(*通讯作者)
书籍章回：
1. Xu H and Wang HL. Small cell carcinoma of the uterine cervix: a sibling of
small cell lung carcinoma? In: New Research on Cervical Cancer. Rolland
GZ, eds, Nova Science Publishers, Inc., Hauppauge, NY. 2007, pp 109-127.
2. Xu H and Wang HL. Cytomegalovirus and human cancers. In: Oncogenic
Virus. Tunely EI, eds, Nova Science Publishers, Inc., Hauppauge, NY. 2007, pp 215-245.
摘要：
1. Xu H, Barry DM, Trimmer JS, Merlie JP and Nerbonne JM. Differential expression of voltage-gated K+ channel subunits and functional K+ channels during postnatal development. Circulation 92:I-372 (1995).
2. Xu H, Barry DM and Nerbonne JM. Molecular correlates of functional Ito and IK channels in rat ventricular myocytes probed with K+ channel toxins and antisense oligonucleotides. Circulation 96:I-421 (1997).
3. Barry DM, Xu H and Nerbonne JM. The Kv4 subfamily contributes to the peak outward K+ current in mouse ventricular myocytes. Circulation 96:I-422 (1997).
4. Barry DM, Xu H and Nerbonne JM. Functional knockout of the cardiac transient outward K+ current in mice expressing a dominant negative voltage-gated K+ channel (Kv4) a subunit. Biophysical Journal 74:A27 (1998).
5. Xu H and Nerbonne JM. Functional knockout of the atrial transient outward K+ current in mice expressing a dominant negative Kv4 a subunit. Circulation 98:I-610 (1998).
6. Xu H, Barry MD, LI H, Bourne S, Guo W and Nerbonne JM. Two distinct components of the slowly inactivating K+ current, IK,slow in mouse ventricular myocytes: a role for Kv2 a subunits. Circulation 100:I351 (1999).
7. Li H, Xu H and Nerbonne JM. Functional expression of a GFP-tagged Kv1.5 a subunit in cardiac myocytes of transgenic mouse. Circulation 100:I-633 (1999).
8. Xu H, Franks TJ, Galvin JR and Travis WD. The impact of chest imaging on the pathologic diagnosis of pulmonary, mediastinal, and pleural disease. Modern Pathology 17 (Supplemental I):345A (2004).
9. LaPoint R JA, Bourne PA, Wang HL and Xu H. Coexpression of c-kit and
bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. Modern Pathology 19:312A (2006).
10. Shishido T, Woo CH, Ding B, McClain, Lu Z, Xu H, Yan C, Abe JI. Angiotensin II and reactive oxygen species (ROS) induce ERK5-SUMOylation and inhibit ERK5 transcriptional activity: impact in diabetic cardiomyopathy (DMC). Circulation 114 (Supplement II):II-84 (2006).
11. Xu H, Bourne PA, Spaulding BO and Wang HL. K homology domain containing protein overexpressed in cancer (KOC) is highly expressed in small and large cell neuroendocrine carcinomas but not in carcinoid tumors of the lung. Modern Pathology 20 (Supplement II):334A (2007).
12. Hanley KZ, Facik MS, Bourne PA, Spaulding BO, Bonfiglio TA and Xu H. Utility of anti-L523S antibody in the diagnosis of benign and malignant pleural effusion. Modern Pathology 20 (Supplement II):334A (2007).
13. Wagner D, Bourne PA, Goldman BI, Lewis, JS Jr. and Xu H. Metastatic malignant pleural mesothelioma in the mediastinal lymph node: a clinico- pathologic-radiologic study of seven cases. Modern Pathology 20 (Supplement II):71A (2007).
14. Pryor JG, Bourne PA, Spaulding BO, Scott GA and Xu H. K homology domain containing protein overexpressed in cancer (KOC) is expressed in malignant melanoma but not in melanocytic nevi. Modern Pathology 20 (Supplement II):98A (2007).
15. Li L, Simon R, Spaulding BO, Bourne PA, Yao JL, di Sant'Agnese PA, Xu H and Huang J. KOC is a useful marker for the classification of urothelial neoplasms of the bladder. Modern Pathology 20 (Supplement II):159A (2007).
16. Shishido T, Woo WH, Ding B, McClain C, Lu Z, Yan C, Xu H and Abe, JI. Blockade of diabetes (DM)-mediated p90RSK activation reduces small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation) and DM-induced exacerbation of left ventricular (LV) remodeling after myocardial infarction (MI). Circulation 116: II-101 (2007).
17. Lu Z, Abe J, Taunton J, and Xu H. Reactive oxygen species-induced p90
ribosomal S6 Kinase activation leads to prolongation of cardiac repolarization via inhibiting voltage-gated outward K+ Currents. Circulation 116: II-118 (2007).
18. Shishido T, Woo CH, Ding B, McClain C, Lu B, Xu H, Yan C, and Abe JI. Association of ERK5 with MEK5 (upstream kinase of ERK5), but not ERK5 kinase activation, inhibits small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation), and prevents diabetes (DM)-mediated exacerbation of left ventricular (LV) remodeling After myocardial infarction (MI). Circulation 116: II-211 (2007).
17. Xu H, Briones AJ, Bourne PA, Spaulding BO, Lu D, Fischer-Colbrie R, Qu Z and Wang HL. KOC, TTF-1 and CDX2 discriminate small cell carcinoma from carcinoid and pancreatic endocrine tumor metastasized to the liver. Modern Pathology 21 (Supplement I):318A (2008).
18. Briones AJ, Bourne PA, Spaulding BO, Lu D, Fischer-Colbrie R, Qu Z, Wang HL and Xu H. Metastatic pancreatic endocrine tumors in the liver express KOC. Modern Pathology 21 (Supplement I):300A (2008).
20. H Xu, R Simon, Bourne PA, Spaulding BO and Wang HL. immunohistochemical analysis of KOC/IMP3 in malignant pleural mesothelioma. Modern Pathology. in press.
21. Miyamoto H, Bourne PA, Qu Z, Yao Y, Wang HL and Xu H. Diagnostic utility of WT1 immunostaining in gastrointestinal stromal tumor. Modern Pathology 21 (Supplement I):130A (2008).
22. Pryor JG, Simon R, Bourne PA, Spaulding BO, Scott GA and Xu H. Merkel cell carcinomas express K homology domain containing protein overexpressed in cancer like small cell carcinomas Modern Pathology 21 (Supplement I):100A (2008).
23. Simon R, Xu H, Bourne PA, Yao JL, Wei J, Liang S, Liu J, di Sant’Agnese, L Cheng and Huang J. CD44 is a useful marker for prostatic small cell carcinoma. Modern Pathology 21 (Supplement I):182A (2008).
24. Kobel M, Xu H, Bourne PA, Spaulding BO, Huntsman D, Gilks CB. IMP3 is an extremely poor prognosis marker for ovarian clear cell carcinoma. Modern Pathology 21 (Supplement I):209A (2008).
25. H Xu, Simon R, Bourne PA, Spaulding BO and Wang HL. Immunohistochemical analysis of KOC/IMP3 in malignant pleural mesothelioma. Modern Pathology 21 (Supplement I):353A (2008).
26. Chuang C, Raymond, Wandtke JC and H Xu.Pathology and PET-FDG correlation studies determine false positive and negative milignancies of the lung. Modern Pathology 22 (Supplement I):353A (2009).
27. Mentrikoski MJ, Ma, L, Pryor, JG, McMahon LA, Spaulding BO, Scott GA,Wang HL and Xu H. Diagnostic utility of IMP3 in segregating metastatic malignant melanomas from benign nevi in lymphnodes. Modern Pathology 22 (Supplement I):351A (2009).
28. Wagner DG, Yang Q, McMahon LA,Spaulding BO, Wang HL and Xu H. IMP3 expression can distinguish hepatocellular carcinoma from hepatocellular adenoma. Modern Pathology 22 (Supplement I):325A(2009).
29. Wagner DG, Yang Q, McMahon LA,Spaulding BO, Wang HL and Xu H. IMP3 expression can distinguish cholangiocarcinoma and metastatic pancreatic ductal carcinoma from benign ductal lesions. Modern Pathology 22 (Supplement I):324A (2009).
30. Findeis-Hosey J, Huang J, Li F, Yang Q,McMahon LA and Xu H. High grade neuroendocrine carcinomas of the lung highly express EZH2 but carcinoids do not. Modern Pathology 22 (Supplement I):350A(2009).
31. Levy M, Lin F, Xu H, DhallD, Spaulding BO, and WangHL. S100P, von HippelLindau gene product (pVHL) and IMP3 serve asa useful immunohistochemical panel in helping diagnose adenocarcinoma on endoscopic bile duct biopsy. Modern Pathology 22 (Supplement I):314A (2009).
32. Chiles L, Levy M, Balzer, B, Xu H, Xiao SY, Zhai J, Soffer, Conklin EJ, Dhall D, Amin MB and WangHL. Characterization of expression of a novel smooth muscle contractile protein smoothelin in gastrointestinal tract: implication in the pathogenesis of chronic intestinal pseudoobstruction. Modern Pathology 22 (Supplement I):126A (2009).
33. Levy M, Dhall D, Zhang J, Miles L,Misdraji J, Yerian LM, Xu Hand Wang HL. Expression of glypican-3 in embryonal sarcoma and mesenchymal hamartoma of the liver: A potential diagnostic pitfall.Modern Pathology 22 (Supplement I):314A (2009).
34. MentrikoskiMJ, ZhaoC, ZhangJ, WangHL,McMahonLA, YangQ, LiF and Xu H.Metastatic endometrial stromal sarcoma in the lung: importance of immunohistochemical staining, clinical history and imaging studies. Modern Pathology23 (Supplement 1):409A (2010).
35. Li F, Wang X, McMahon LA, Yang Q and Xu H. Minute nests of neuroendocrine cells in the mediastinal lymph nodes: real metastasis? Modern Pathology 23 (Supplement 1):407A (2010).
36. Ye J, Findeis-Hosey JJ, McMahon LA,Yang Q, Li F and Xu H. Usefulness of Napsin A and TTF-1 in discriminating metastatic carcinoma from primary adenocarcinoma of the lung.Modern Pathology 23 (Supplement 1):415A-416A (2010).
37. Findeis-Hosey JJ, Yang Q, McMahon, LA,Spaulding BO, F Li and Xu H. IMP3: An immunohistochemical marker for invasive squamous cell carcinoma and Its high-grade precursor lesions of the lung.Modern Pathology 23 (Supplement 1):402A (2010).
38. Findeis-Hosey JJ, Yang Q, McMahon, LA,Spaulding BO, F Li and Xu H. Usefulness of EZH2 and IMP3 in discriminating high grade neuroendocrine carcinoma from carcinoids in small biopsies and fine needle aspiration specimens of the lung. Modern Pathology 23 (Supplement1):401A (2010).
39. Findeis-Hosey JJ, Yang Q, McMahon, LA, F Li and Xu H. Napsin A is frequently expressed in pulmonary adenocarcinoma but rarely detected in neuroendocrine tumors of the lung. Modern Pathology23 (Supplement 1):401A-402A (2010).
40. Thunnissen E, Beasly M, BorczukA, BrambillaE, ChirieacLR, FliederD,GazdarA, KeisingerK, HasletonP, IshikawaY, KerrK, atsunoY, MinamiY, MoreiraA,MotoiN, NicholsonA, NoguchiM, NonakaD, PelosiG, PetersenI, RekhtmanN, RoggliV, TravisB,TsaoM, WistubaI, XuH, Yatabe Y andKuikJ. Reproducibility of histopathological subtypes in pulmonaryadenocarcinoma. An international interobserver study. Modern Pathology 23(Supplement 1):415A (2010).
41. FanLF, Datta V, Riley-PortugesA,LopateguiJ, LinF, XuHand Wang HL. EGFR Expression and KRAS mutation in cholangiocarcinoma: implication in EGFRtargeted therapies. Modern Pathology 23(Supplement 1):354A (2010).
42. Ye B, Xu Hand Li F. Cardiac beta-catenin deletion mediated by alpha-MHC promoter causes ventricular hypoplasia. Circulation 122:A18584 (2010).
43. Mao W, Lu Y, Alexis JD, Li F and Xu H. Foxo1 regulates cardiac sodium channel (NaV1.5) expression in mouse ventricular hypertrophy and failure induced by transverse aortic constriction. Circulation 122:A17271 (2010).
44. Findeis-Hosey JJ, McMahon LA, Yang Qand Li F and Xu H. Increase of EZH2 expression in bronchiolar epithelial cellsin smoking-related diseases of the lung. Modern Pathology 24 (Supplement1):408A-409A (2011).
45. Findeis-Hosey JJ, McMahon LA, Yang Q and Li F and Xu H. EZH2 expression is correlated with histologic grade of lung adenocarcinoma. Modern Pathology 24(Supplement 1):409A (2011).
46. Findeis-Hosey JJ, McMahon LA, Yang Q and Li F and Xu H. EZH2 expression in invasive squamous cell carcinoma of the lung and its precursor lesions.Modern Pathology 24 (Supplement 1):409A (2011).
47. Choy B, Findeis-Hosey JJ,McMahon LA,Yang Q and Li F and Xu H. Coexpression of maspin with p63 and p53 insquamous cell carcinoma but not in adenocarcinoma of the lung. Modern Pathology 24(Supplement 1):407A (2011).
48. Ye J, Hammed O, Findeis-Hosey JJ, Fan L, Li F, McMahonLA, Yang Q, Wang HLand Xu H. Diagnostic Utility of PAX8, NapsinA and TTF-1 in discriminating metastatic carcinoma from primary non-small cell carcinoma of the lung. Modern Pathology24 (Supplement 1):429A (2011).
49. Lloyd J, Xu Hand Zhao C. CDX2 is a useful marker to distinguish ovarian primary carcinoid from metastasis. Modern Pathology 24 (Supplement 1):258A (2011).
50. Schmidt MT, Chung F, Lin F, Xu, Hand Wang HL. Use of S100P, IMP3 and pVHL immunopanel to aid in the interpretation of bile duct biopsies with atypical histology or suspicious for malignancy.Modern Pathology 24 (Supplement 1):374A (2011).
51. Ye B, Mao W, McMahon LA, Yang Q, Xu Hand Li F. Chromatin remodeling and cell cycle activity in periinfarction myocardium. Modern Pathology 24 (Supplement 1):80A(2011).
52. Cappel J, Findeis-Hosey JJ, McMahon LA,Yang Q, Xu Hand Li F. MASH1: A specific immunohistochemical marker for high grade neuroendocrine tumors of the lung. Modern Pathology 24 (Supplement1):406A (2011).
53. Mao W, Lu Y, You T, Li F and Xu H.Enhancement of Foxo proteins suppressing NaV1.5 expression by reactive oxygen species in chronic ischemic heart disease. Circulation 124:A13459(2011).
54. Bo Y, Xu H, Li F. Cardiac specific deletion of adenomatous polyposis coli promotes cardiomyocyte hyperplasia.Circulation 124:A13121 (2011).
55. Ye J, Fiscella J, Honnons S, McMAhonLA,Yang Q,Li F and Xu H. PAX8 is useful in discriminating metastatic endometrioid carcinoma even with infrequent TTF-1 and napsin A positivity from primary lung adenocarcinoma. Modern Pathology 25 (Supplement 2):493A (2012).
56. Cai B, Mao W, Tao, Y, Li F and Xu H.Cardiac deletion of Foxo1 leads to shortening of QRS by enhancing NaV1.5 expression and Na+currents in adult mice. Circulation 126: A13336 (2012).
57. Bo Y, Xu H, and Li F. Cardiac deletion of Brg1 chromatin remodeling ATPase causes dilated cardiomyopathy. Circulation 126:A17882, 2012.
58. Bo Y, Xu H, and Li F. Canonical Wnt/beta-catenin signaling during late embryonic heart development. Circulation 126:A17882, 2012.
59. Ren B, McMahon L, Yang Q, Wang N,Rothberg P, Zhou Z, Li L and Xu H. ALK protein expression correlates with ALK rearrangement, but not increased ALKcopy number in lung adenocarcinomas. Modern Pathology 26 (Supplement 2):465A (2013).
60. Ye B, Hou N, Xiao L, XuH, and Li F.Assessment of oxidative DNA double strand break and Rrepair in cardiomyocytes.Circulation Research. 2013;113:A265.
61. Hou N, Ye B, Xiao L, Xu H, and Li F.Tcf7l2 expression by insulin and high glucose. Circulation Research.2013;113:A287.
62. Xiao L, Bai H, Boyer J, Ye B, Hou N,Xu H, and Li F. Tcf7l2 expression and isoform switching in mouse hearts.Circulation Research. 2013;113:A293.
63.Wang N, Cai B, Li X,Lu Y, Ye B, Li F and Xu H. β-Catenin inhibition of NaV1.5 requires both TCF4 and FoxO1 in cardiomyocytes. Circulation (2013).
受邀陈述：
1. Differential expression of voltage-gated K+ channel subunits and functional K+ channels during postnatal development. American Heart Association-68th Scientific Sessions, November, 1995 (Los Angeles, CA).
2. Molecular correlates of functional Ito and IK channels in rat ventricular myocytes probed with K+ channel toxins and antisense oligonucleotides. American Heart Association-70th Scientific Sessions, November, 1997 (Orlando, FL).
3. Functional knockout of the cardiac transient outward K+ current in mice expressing a dominant negative voltage-gated K+ channel (Kv4) a subunit. Biophysical Society-Forty-Second Annual Meeting, February, 1998 (Kansas, MO).
4. Functional knockout of the atrial transient outward K+ current in mice expressing a dominant negative Kv4 a subunit. American Heart Association-71th Scientific Sessions, November, 1998 (Dallas, TX).
5. Two distinct components of the slowly inactivating K+ current, IK,slow in mouse ventricular myocytes: a role for Kv2 a subunits. American Heart Association-72th Scientific Sessions, November, 1999 (Atlanta, GA).
6. The impact of chest imaging on the pathologic diagnosis of pulmonary, mediastinal, and pleural disease. United States and Canadian Academy of Pathology, 93rd Annual meeting, 2004 (Vancouver, BC. Canada).
7. K homology domain containing protein overexpressed in cancer (KOC) is highly expressed in small and large cell neuroendocrine carcinomas but not in carcinoid tumors of the lung. USCAP 96th annual meeting, 2007 (San Diego, CA).
8. Reactive Oxygen Species-Induced p90 Ribosomal S6 Kinase Activation Prolongs Cardiac Repolarization via Inhibiting Voltage-Gated Outward K+ Currents. Upstate New York Cardiac Electrophysiology Society17th Annual Meeting, 2007 (Rochester, NY).
9. KOC, TTF-1 and CDX2 discriminate small cell carcinoma from carcinoid and pancreatic endocrine tumor metastasized to the liver. Will be presented in USCAP 97th annual meeting, 2008 (Denver, CO).
受邀演讲：
1. Molecular dissection of cardiac repolarization. Soochow University Medical School, Suzhou, P.R. China. September 24, 2002.
2. Molecular mechanisms underlying cardiac repolarization. Cardiovascular Research Institute, University of Rochester Medical Center, USA. February 21, 2007.
3. Idiopathic pulmonary fibrosis. Chinese Pathology Society’s Annual Meeting at Chengdu, P.R. China. April 20-23, 2007.
4. Idiopathic pulmonary fibrosis-UIP. First Affiliated Hospital, Soochow University Medical School, Suzhou, P.R. China. April 26, 2007.
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