--本文经《美国外科病理学杂志》授权发布，其他媒体转载或引用须经《美国外科病理学杂志》同意，否则追究法律责任。
摘要：肺淋巴上皮瘤样癌（lymphoepithelioma-like carcinoma，LELC）是一种少见的EB病毒（Epstein-Barr virus，EBV）相关性癌。其组织学特征是合体样生长方式伴有明显的淋巴细胞浸润，在组织学上与未分化鼻咽癌无法区分。然而，已有研究发现，LELC可以表现为非经典形态并缺乏显著的淋巴细胞浸润。本研究中，我们对61例肺LELC患者进行了系统的临床病理分析，并使用IHC分析软件对淋巴细胞浸润进行自动定量分析。结果表明，肺LELC具有形态学上的连续性，从具有高密度淋巴细胞浸润的经典低分化肿瘤形态，到几乎没有淋巴细胞浸润的非经典形态。这些EBV相关性肿瘤代表了一类特殊疾病，通常发生于女性和非吸烟患者。低密度淋巴细胞浸润的肿瘤与非角化性鳞状细胞癌非常相似，通常瘤体较大、在影像学上具有更高的最大标准化摄取值，且复发时间短于具有高密度淋巴细胞浸润的肿瘤。通过细致的病理检查，我们观察到一些肺LELC独特的形态学特征，包括肉芽肿性炎、局灶角化、肺泡腔播散及附壁样播散方式。我们还发现，表现为肉芽肿性炎的肿瘤患者预后较好；但是，是否存在肺泡腔播散与预后没有显著相关性。由于这些“LELC”与未分化鼻咽癌或淋巴上皮癌不同，我们建议使用另一个术语，EBV相关性肺癌，以涵盖这一特殊疾病的全部形态谱系。
关键词：淋巴上皮瘤样癌、EB病毒、淋巴细胞、鳞状细胞癌、肺泡腔播散
（Am J Surg Pathol 2019；43：211-219）
美国外科病理学杂志中文版2019年第三期摘要NO.9
( 吴江华 翻译 林冬梅 审校 )
The American Journal of Surgical Pathology中文版声明：
©2018 Wolters Kluwer Health
The material is published by Wolters Kluwer Health with the permission of American Journal of Surgical Pathology.No part of this publication may be reproduced in any form,stored in a retrieval system or transmitted in any form,by any means,without prior written permission from Wolters Kluwer Health.Opinions expressed by the authors and advertisers are not necessarily those of the American Journal of Surgical Pathology, its affiliates,or of the Publisher.The American Journal of Surgical Pathology,its affiliates,and the Publisher disclaim any liability to any party for the accuracy,completeness,efficacy,or availability of the material contained in this publication (including drug dosages) or for any damages arising out of the use or non-use of any of the material contained in this publication.
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【本文经《美国外科病理学杂志》授权发布，其他媒体转载或引用须经《美国外科病理学杂志》同意 ，否则追究法律责任；所有文章仅供公益交流，不代表本站立场。欢迎提供素材、资料等，投稿邮箱： tougao@91360.com，一经采纳将给予稿费】
©2018 Wolters Kluwer Health
The material is published by Wolters Kluwer Health with the permission of American Journal of Surgical Pathology.No part of this publication may be reproduced in any form,stored in a retrieval system or transmitted in any form,by any means,without prior written permission from Wolters Kluwer Health.Opinions expressed by the authors and advertisers are not necessarily those of the American Journal of Surgical Pathology, its affiliates,or of the Publisher.The American Journal of Surgical Pathology,its affiliates,and the Publisher disclaim any liability to any party for the accuracy,completeness,efficacy,or availability of the material contained in this publication (including drug dosages) or for any damages arising out of the use or non-use of any of the material contained in this publication.
Although advertising material is expected to conform to ethical (medical) standards,inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer.
【本文经《美国外科病理学杂志》授权发布，其他媒体转载或引用须经《美国外科病理学杂志》同意 ，否则追究法律责任；所有文章仅供公益交流，不代表本站立场。欢迎提供素材、资料等，投稿邮箱： tougao@91360.com，一经采纳将给予稿费】
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