EBV阳性黏膜皮肤溃疡的病理特征包含9例病例的研究
  --本文经《美国外科病理学杂志》授权发布,其他媒体转载或引用须经《美国外科病理学杂志》同意,否则追究法律责任。
  本文分析了9例EB病毒(Epstein-Barrvirus,EBV)阳性黏膜皮肤淋巴组织增生性病变的病理特征,这拓展了EBV阳性黏膜皮肤溃疡的概念。9例病例中有女性5例和男性4例,平均年龄74岁(范围,55~87岁),其中2例为HIV阳性患者。病变位于口咽、皮肤、直肠和生殖器黏膜。组织病理学上,6例显示出多形性以及3例表现为单形性和弥漫性,4例表现出血管改变(具有多形性和单形性模式各2例)。其中3例表达PDL1。除了在肿瘤性淋巴细胞中表达外,在1例口咽部病变的相邻黏膜上皮细胞中同样检测到了EBV。9例病例在进行了局部治疗或系统性化疗后,病变均有改善或消退。本文通过对9例病例的分析,
  扩展了EBV阳性黏膜皮肤溃疡的疾病谱系,包括HIV阳性病例、局限于单一解剖区域的多处病灶、具有血管中心性病变模式以及一些具有单一大细胞形态的病例。本文同时讨论了EBV阳性黏膜皮肤溃疡与经典EBV阳性大B细胞淋巴瘤的不同临床病理诊断特征。
  Am J Surg Pathol 2019;43:187-194
  美国外科病理学杂志中文版2019年第三期摘要NO.2
  (任华艳 翻译 李晟磊 审校)
  The American Journal of Surgical Pathology中文版声明:
  ©2018 Wolters Kluwer Health
  The material is published by Wolters Kluwer Health with the permission of American Journal of Surgical Pathology.No part of this publication may be reproduced in any form,stored in a retrieval system or transmitted in any form,by any means,without prior written permission from Wolters Kluwer Health.Opinions expressed by the authors and advertisers are not necessarily those of the American Journal of Surgical Pathology, its affiliates,or of the Publisher.The American Journal of Surgical Pathology,its affiliates,and the Publisher disclaim any liability to any party for the accuracy,completeness,efficacy,or availability of the material contained in this publication (including drug dosages) or for any damages arising out of the use or non-use of any of the material contained in this publication.
  Although advertising material is expected to conform to ethical (medical) standards,inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer.
  【本文经《美国外科病理学杂志》授权发布,其他媒体转载或引用须经《美国外科病理学杂志》同意 ,否则追究法律责任;所有文章仅供公益交流,不代表本站立场。欢迎提供素材、资料等,投稿邮箱: tougao@91360.com,一经采纳将给予稿费】