摘要：本文的目的是研究肾小管上皮源性的小肿瘤；对来自402例未经筛选的尸体解剖肾脏标本每间隔1至2mm进行切片。对所有病变进行组织学检查。在76例患者（19%）中共发现232个乳头状腺瘤，范围为1~35个腺瘤/患者（平均：3，中位数：2）。乳头状腺瘤患者年龄较大（范围：27~90岁）（P<0.0001），更常见于吸烟者（P=0.01），并且更常伴有肾小球硬化症（P=0.0001）。乳头状腺瘤大小为0.5~5mm（平均：1.4，中位数：1），形态上分为4种亚型。A型腺瘤由乳头和/或小管组成，肿瘤细胞胞浆少，通常伴有砂砾体，是最常见的亚型（149个腺瘤）。B型有30例，乳头宽，轴心内有淋巴细胞浸润。C型共30例，呈囊性，被覆柱状细胞，并含有巨噬细胞和砂砾体。D型16例，由大的嗜酸性细胞组成，核呈假复层，偶尔靠近胞浆顶端。有4例不能归类。仅观察到1例混合型（1例患者中有3个腺瘤，每个均为B和D型混合）。其他上皮性病变包括31个肾上腺残余、5个嗜酸细胞腺瘤、2个透明细胞乳头状肾细胞癌、2个管状囊性肾细胞癌和2个获得性囊性疾病相关的肾细胞癌。总之，乳头状腺瘤是最常见的小上皮性肿瘤。第1种亚型（A型）的乳头状腺瘤与1型乳头状肾细胞癌非常类似，第4种亚型（D型）与2型乳头状肾细胞癌类似。未发现其他类型的肾细胞肿瘤（包括透明细胞肾细胞癌和嫌色性肾细胞癌）。没有发现肾源性残余。血管平滑肌脂肪瘤和肾髓质间质细肿瘤也有被发现，这些之前也有文章报道过。
关键词：乳头状腺瘤，肾脏，尸检
（Am J Surg Pathol 2019；43：277-287）美国外科病理学杂志中文版2019年第三期摘要NO.12
( 葛 莉 翻译 卢朝辉 审校 )
The American Journal of Surgical Pathology中文版声明：
©2018 Wolters Kluwer Health
The material is published by Wolters Kluwer Health with the permission of American Journal of Surgical Pathology.No part of this publication may be reproduced in any form,stored in a retrieval system or transmitted in any form,by any means,without prior written permission from Wolters Kluwer Health.Opinions expressed by the authors and advertisers are not necessarily those of the American Journal of Surgical Pathology, its affiliates,or of the Publisher.The American Journal of Surgical Pathology,its affiliates,and the Publisher disclaim any liability to any party for the accuracy,completeness,efficacy,or availability of the material contained in this publication (including drug dosages) or for any damages arising out of the use or non-use of any of the material contained in this publication.
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【本文经《美国外科病理学杂志》授权发布，其他媒体转载或引用须经《美国外科病理学杂志》同意 ，否则追究法律责任；所有文章仅供公益交流，不代表本站立场。欢迎提供素材、资料等，投稿邮箱： tougao@91360.com，一经采纳将给予稿费】
©2018 Wolters Kluwer Health
The material is published by Wolters Kluwer Health with the permission of American Journal of Surgical Pathology.No part of this publication may be reproduced in any form,stored in a retrieval system or transmitted in any form,by any means,without prior written permission from Wolters Kluwer Health.Opinions expressed by the authors and advertisers are not necessarily those of the American Journal of Surgical Pathology, its affiliates,or of the Publisher.The American Journal of Surgical Pathology,its affiliates,and the Publisher disclaim any liability to any party for the accuracy,completeness,efficacy,or availability of the material contained in this publication (including drug dosages) or for any damages arising out of the use or non-use of any of the material contained in this publication.
Although advertising material is expected to conform to ethical (medical) standards,inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer.
【本文经《美国外科病理学杂志》授权发布，其他媒体转载或引用须经《美国外科病理学杂志》同意 ，否则追究法律责任；所有文章仅供公益交流，不代表本站立场。欢迎提供素材、资料等，投稿邮箱： tougao@91360.com，一经采纳将给予稿费】
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