本文报道了13例类似甲状腺高细胞亚型乳头状肿瘤的乳腺浸润性实性乳头状癌（breast tumors resembling the tall cell variant of papillary thyroid carcinoma,BPTC）。部分病例长期随访。BPTC是一种低侵袭潜能的特殊类型原发性三阴性乳腺癌。由于对BPTC了解甚少，本文旨在探讨13例BPTC患者的临床病理特征。13例患者均为女性，发病时平均年龄62.6岁；结节大小0.6到2.5cm（平均1.6cm）。组织学以乳头状、滤泡状和实性结构为特征。瘤细胞呈柱状，多数胞浆呈嗜酸颗粒状，富含线粒体，7例以上含有嗜酸细胞特征。雌激素受体（estrogen receptor,ER）、孕激素受体（progesterone receptor,PR）及人表皮生长因子受体2（human epidermal growth factor receptor 2,HER2）均阴性。Ki67增殖指数较低。甲状腺特异性标记物，如甲状腺转录因子1（Thyroid transcription factor 1,TTF1）和甲状腺球蛋白（thyroglobulin,Tg）为阴性。5例标记了乳球蛋白和GATA 3均阳性。所有病例均为浸润性，其中2例分别转移至1处淋巴结（腋窝和乳腺内），后者出现局部复发。所有患者术后随访24~132月均无瘤存活，其中8例除手术切除外未行进一步治疗。本研究证实BPTC是具有低度恶性潜能的原发性乳腺肿瘤。

　　乳腺、甲状腺样癌、乳头状癌

　　来源：Am J Surg Pathol 2017;41:887–895

　　美国外科病理学杂志中文版2017年第一期全文No.4

　　（潘敏鸿/朱芸  翻译；张智弘 审校）
 

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